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Chapter 19 - Spinal Tumors
- from Section 2 - Clinical Neurosurgical Diseases
- Edited by Farhana Akter, Harvard University, Massachusetts, Nigel Emptage, University of Oxford, Florian Engert, Harvard University, Massachusetts, Mitchel S. Berger, University of California, San Francisco
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- Book:
- Neuroscience for Neurosurgeons
- Published online:
- 04 January 2024
- Print publication:
- 25 January 2024, pp 267-277
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Summary
Tumors of the spine are a heterogeneous group of neoplasms involving the spinal column and spinal cord. They can be distinguished based on their location within the spine into three groups: intradural–intramedullary, intradural–extramedullary, and extradural. Another classification seeks to separate out these tumors based on their cell of origin, with primary spine tumors arising from either the spinal cord itself, its surrounding coverings including the leptomeninges, bone, cartilage, and soft tissue, or as secondary tumors arising from spinal involvement of a systemic neoplasm such as myeloma or as a metastasis from a distant site. This chapter seeks to discuss current evidence on the genetic, epigenetic, and cellular underpinnings of spine tumors with emphasis on the pathobiology and mechanisms underlying these neoplasms.
Pilot study of a ketogenic diet in bipolar disorder
- Nicole Needham, Iain H. Campbell, Helen Grossi, Ivana Kamenska, Benjamin P. Rigby, Sharon A. Simpson, Emma McIntosh, Pankaj Bahuguna, Ben Meadowcroft, Frances Creasy, Maja Mitchell-Grigorjeva, John Norrie, Gerard Thompson, Melissa C. Gibbs, Ailsa McLellan, Cheryl Fisher, Tessa Moses, Karl Burgess, Rachel Brown, Michael J. Thrippleton, Harry Campbell, Daniel J. Smith
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- Journal:
- BJPsych Open / Volume 9 / Issue 6 / November 2023
- Published online by Cambridge University Press:
- 10 October 2023, e176
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Background
Recent evidence from case reports suggests that a ketogenic diet may be effective for bipolar disorder. However, no clinical trials have been conducted to date.
AimsTo assess the recruitment and feasibility of a ketogenic diet intervention in bipolar disorder.
MethodEuthymic individuals with bipolar disorder were recruited to a 6–8 week trial of a modified ketogenic diet, and a range of clinical, economic and functional outcome measures were assessed. Study registration number: ISRCTN61613198.
ResultsOf 27 recruited participants, 26 commenced and 20 completed the modified ketogenic diet for 6–8 weeks. The outcomes data-set was 95% complete for daily ketone measures, 95% complete for daily glucose measures and 95% complete for daily ecological momentary assessment of symptoms during the intervention period. Mean daily blood ketone readings were 1.3 mmol/L (s.d. = 0.77, median = 1.1) during the intervention period, and 91% of all readings indicated ketosis, suggesting a high degree of adherence to the diet. Over 91% of daily blood glucose readings were within normal range, with 9% indicating mild hypoglycaemia. Eleven minor adverse events were recorded, including fatigue, constipation, drowsiness and hunger. One serious adverse event was reported (euglycemic ketoacidosis in a participant taking SGLT2-inhibitor medication).
ConclusionsThe recruitment and retention of euthymic individuals with bipolar disorder to a 6–8 week ketogenic diet intervention was feasible, with high completion rates for outcome measures. The majority of participants reached and maintained ketosis, and adverse events were generally mild and modifiable. A future randomised controlled trial is now warranted.
10 - Unarmed Civilian Protection and Nonviolence with Attention to Sub-Saharan Africa
- Edited by Ellen Furnari, Randy Janzen, Rosemary Kabaki
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- Book:
- Unarmed Civilian Protection
- Published by:
- Bristol University Press
- Published online:
- 18 January 2024
- Print publication:
- 21 June 2023, pp 115-125
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Summary
Although there is a growing body of literature on nonviolence, there are fewer writings on the relationship between unarmed civilian protection (UCP) and nonviolence and how the two concepts work together in practice. This chapter will bridge this gap, arguing that nonviolence is not only UCP's principal but is its overall guiding concept. To this end, the chapter discusses how different scholars and practitioners define nonviolence, its principles and methods, including: protests, non-cooperation, and nonviolent direct intervention, where UCP originated from and what their relationship is. It further explores past and contemporary examples of successful use of nonviolent actions and how UCP activities contributed to protection of civilians and activists in their efforts to prevent violence, improve security and build peace. The chapter concludes that the Indigenous people and societies are the custodians of UCP, as they have paramount responsibility to create and sustain their own protection and nonviolent action methods, strategies and mechanisms.
Background
Research on nonviolence has never dominated the academic field of Peace Studies (John, 2022, p 359). Evidently, many library shelves in Peace Study colleges are filled with books on wars and people's armed conflicts (Johansen, 2009, p 69). However, following the wave of nonviolent movements in 2011 onwards that yielded dramatic results, there is a growing body of literature on nonviolence. However, very little attention has been paid to highlighting the contributions of unarmed civilian protection (UCP), also referred to as unarmed civilian peacekeeping, in people's struggle for better protection, governance and service delivery.
While the extent and intensity of wars and conflicts in sub-Saharan Africa decreased in the 1990s, the region remains prone to conflicts, with about 30 per cent of the region's countries affected in 2019 (Fang et al, 2020, p 2). However, against the same backdrop, the Uppsala Conflict Data Program (UCDP) reveals 56 state-based conflicts in 2020, including eight wars. Most of these conflicts occurred in Africa, as the region registered 30 state-based conflicts, including nine new or restarted ones (Pettersson et al, 2020, p 2). Civilians have increasingly become victims in situations of wars, armed conflicts and where there is negative peace with a prevalence of structural injustices.
Manning Clark’s Repudiation of Anglicanism and the Appeal of ‘Sentimental Humanism’ in his Quest for Grace
- John A. Moses
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- Journal:
- Journal of Anglican Studies / Volume 22 / Issue 1 / May 2024
- Published online by Cambridge University Press:
- 24 April 2023, pp. 197-211
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Manning Clark is regarded as a pioneer of Australian national history. His output has been unequalled but it has provoked a vigorous division of opinions concerning its accuracy and the all-pervading thesis that Australia, to achieve its true national self-perception, must throw off the British heritage that included the baleful influence of the Anglicanism in which Clark was raised by his priest father. Here the work of three key scholarly critics, namely Dr George Shaw, Professor Brian Fletcher and Professor Alan Atkinson is evaluated, all of whom are Anglican historians of Australia. They have made very different assessments of the evolution of Australian national identity and the permanence of the British heritage. Shaw, as a former student of Clark, has assessed his mentor’s work not as rigorous history but essentially as ‘sentimental humanism’. As well, the opportunity is taken to reflect on the two extensive biographies of Clark, namely by Brian Matthews and Mark McKenna. Both these men were educated as Roman Catholics at a time when Rome was decidedly allergic to the idea of ecumenical outreach. Consequently, it is argued here that an accurate assessment of Manning Clark’s oeuvre is yet to be accomplished.
An Anglican Odyssey: The Ecumenical Vision of Canon David John Garland (1864–1939) OBE and his Hidden Christian Agenda for Anzac Day
- John A. Moses
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- Journal:
- Journal of Anglican Studies / Volume 21 / Issue 1 / May 2023
- Published online by Cambridge University Press:
- 26 November 2021, pp. 53-69
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There is still much unclear about the nature of the origins of Australia’s most respected and hallowed national day, namely Anzac Day, 25 April, and about who was primarily responsible for instituting a day of solemn commemoration for the fallen in the Great War of 1914–18. Much has been written by mostly unqualified would-be ‘authorities’ that is either patently false, uninformed or hostile to the commemoration. This is either because of resentment in some quarters of the distinctly Anglican contribution to the nature of the commemoration or pacifist misunderstanding that the celebration of Anzac Day is somehow a glorification of war. This paper based on original research into the files of the Queensland Anzac Day Commemoration Committee establishes the key role of Canon David John Garland (1864–1939) in shaping a liturgy of civic religion for the day which he hoped would become a means of reminding the population of their calling as part of the British Empire to emphasize the reign of Almighty God over all nations of the earth. That was the hidden Christian agenda in the mind of Canon Garland. Naturally he had his opponents to this objective.
Planning for patient-reported outcome implementation: Development of decision tools and practical experience across four clinics
- Therese A. Nelson, Brigitte Anderson, Jiang Bian, Andrew D. Boyd, Shirley V. Burton, Kristina Davis, Yi Guo, Bhrandon A. Harris, Kelly Hynes, Karl M. Kochendorfer, David Liebovitz, Kayla Martin, François Modave, John Moses, Nicholas D. Soulakis, Donald Weinbrenner, Sonya H. White, Nan E. Rothrock, Annette L. Valenta, Justin B. Starren
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- Journal:
- Journal of Clinical and Translational Science / Volume 4 / Issue 6 / December 2020
- Published online by Cambridge University Press:
- 06 April 2020, pp. 498-507
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Introduction:
Many institutions are attempting to implement patient-reported outcome (PRO) measures. Because PROs often change clinical workflows significantly for patients and providers, implementation choices can have major impact. While various implementation guides exist, a stepwise list of decision points covering the full implementation process and drawing explicitly on a sociotechnical conceptual framework does not exist.
Methods:To facilitate real-world implementation of PROs in electronic health records (EHRs) for use in clinical practice, members of the EHR Access to Seamless Integration of Patient-Reported Outcomes Measurement Information System (PROMIS) Consortium developed structured PRO implementation planning tools. Each institution pilot tested the tools. Joint meetings led to the identification of critical sociotechnical success factors.
Results:Three tools were developed and tested: (1) a PRO Planning Guide summarizes the empirical knowledge and guidance about PRO implementation in routine clinical care; (2) a Decision Log allows decision tracking; and (3) an Implementation Plan Template simplifies creation of a sharable implementation plan. Seven lessons learned during implementation underscore the iterative nature of planning and the importance of the clinician champion, as well as the need to understand aims, manage implementation barriers, minimize disruption, provide ample discussion time, and continuously engage key stakeholders.
Conclusions:Highly structured planning tools, informed by a sociotechnical perspective, enabled the construction of clear, clinic-specific plans. By developing and testing three reusable tools (freely available for immediate use), our project addressed the need for consolidated guidance and created new materials for PRO implementation planning. We identified seven important lessons that, while common to technology implementation, are especially critical in PRO implementation.
Stuart Piggin and Robert D. Linder (eds.), The Fountain of Public Prosperity: Evangelical Christians in Australian History 1740–1914 (Melbourne: Monash University Publishing, 2018), pp. xiv + 674. ISBN 978-1-925523-46-1 (hbk). RRP $49.95 or £38.50.
- John A. Moses
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- Journal:
- Journal of Anglican Studies / Volume 17 / Issue 1 / May 2019
- Published online by Cambridge University Press:
- 27 December 2018, pp. 104-105
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Paul Collins, Absolute Power: How the Pope Became the Most Influential Man in the World (New York: BBS Public Affairs, 2018), pp. xii+366. US$28.00/£15.00. ISBN 978-1-61039-860-2.
- John A. Moses
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- Journal:
- Journal of Anglican Studies / Volume 16 / Issue 2 / November 2018
- Published online by Cambridge University Press:
- 30 August 2018, pp. 221-223
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Personality Polygenes, Positive Affect, and Life Satisfaction
- Alexander Weiss, Bart M. L. Baselmans, Edith Hofer, Jingyun Yang, Aysu Okbay, Penelope A. Lind, Mike B. Miller, Ilja M. Nolte, Wei Zhao, Saskia P. Hagenaars, Jouke-Jan Hottenga, Lindsay K. Matteson, Harold Snieder, Jessica D. Faul, Catharina A. Hartman, Patricia A. Boyle, Henning Tiemeier, Miriam A. Mosing, Alison Pattie, Gail Davies, David C. Liewald, Reinhold Schmidt, Philip L. De Jager, Andrew C. Heath, Markus Jokela, John M. Starr, Albertine J. Oldehinkel, Magnus Johannesson, David Cesarini, Albert Hofman, Sarah E. Harris, Jennifer A. Smith, Liisa Keltikangas-Järvinen, Laura Pulkki-Råback, Helena Schmidt, Jacqui Smith, William G. Iacono, Matt McGue, David A. Bennett, Nancy L. Pedersen, Patrik K. E. Magnusson, Ian J. Deary, Nicholas G. Martin, Dorret I. Boomsma, Meike Bartels, Michelle Luciano
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- Journal:
- Twin Research and Human Genetics / Volume 19 / Issue 5 / October 2016
- Published online by Cambridge University Press:
- 22 August 2016, pp. 407-417
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Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes <0.05%) were observed between the extraversion polygenic score and wellbeing measures, and a negative association was observed between the polygenic neuroticism score and life satisfaction. Furthermore, using GWA data, genetic correlations of -0.49 and -0.55 were estimated between neuroticism with life satisfaction and positive affect, respectively. The moderate genetic correlation between neuroticism and wellbeing is in line with twin research showing that genetic influences on wellbeing are also shared with other independent personality domains.
CRITICAL SOIL ORGANIC CARBON RANGE FOR OPTIMAL CROP RESPONSE TO MINERAL FERTILISER NITROGEN ON A FERRALSOL
- PATRICK MUSINGUZI, PETER EBANYAT, JOHN STEPHEN TENYWA, TWAHA ALI BASAMBA, MOSES MAKOOMA TENYWA, DRAKE N. MUBIRU
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- Journal:
- Experimental Agriculture / Volume 52 / Issue 4 / October 2016
- Published online by Cambridge University Press:
- 18 January 2016, pp. 635-653
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Soil Organic Carbon (SOC) is a major indicator of soil fertility in the tropics and underlies variability in crop response to mineral fertilizers. Critical SOC concentrations that interact positively with N fertilizer for optimal crop yield are less understood. A study was conducted on a Ferralsol in sub-humid Uganda to explore the critical range of SOC concentrations and associated fractions for optimal maize (Zea mays L.) yield response to applied mineral N fertiliser. Maize grain yield response to N rates applied at 0, 25, 50 and 100 kg N ha−1 in 30 fields of low fertility (SOC < 1.2%), medium fertility (SOC = 1.2–1.7%) and high fertility (SOC > 1.7%) was assessed. Soil was physically fractionated into sand-sized (63–2000 µm), silt-sized (2–63 µm) and clay-sized (<2 µm) particles and SOC content determined. Low fertility fields (<1.2% SOC) resulted in the lowest response to N application. Fields with >1.2% SOC registered the highest agronomic efficiency (AE) and grain yield. Non-linear regression models predicted critical SOC for optimal yields to be 2.204% at the 50 kg N ha−1 rate. Overall, models predicted 1.9–2.2% SOC as the critical concentration range for high yields. The critical range of SOC concentrations corresponded to 3.5–5.0 g kg−1 sand-sized C and 9–11 g kg−1 for clay-sized C.
Shrinking the lymphatic filariasis map: update on diagnostic tools for mapping and transmission monitoring
- MARIA P. REBOLLO, MOSES JOHN BOCKARIE
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- Journal:
- Parasitology / Volume 141 / Issue 14 / December 2014
- Published online by Cambridge University Press:
- 16 September 2014, pp. 1912-1917
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Lymphatic filariasis (LF), which is highly endemic in 73 countries worldwide, is targeted for elimination by 2020. The strategy for achieving this goal is based on 4 sequential programmatic steps: mapping, Mass drug administration (MDA) implementation, post-MDA surveillance and verification of LF elimination. All 4 stages of the implementation process are dependent on the availability of user friendly and highly sensitive rapid diagnostic tools. By the end of 2012, 59 countries had completed mapping for LF and Eritrea was the only country yet to start the process. Rolling out new diagnostic tools to facilitate the mapping process will enable an accelerated shrinking of the LF map to zero endemic countries by 2020. When the Global Programme to Eliminate Lymphatic Filariasis was launched in 2000, diagnostic tools for LF were limited to clinical examination, detection of microfilaria (MF) by microscopy in night blood samples and detection of antibodies to native-antigen preparations. There has been a significant improvement in the traditional LF diagnostic methods in recent years and some new tools are now available. This paper provides an update on the human diagnostic tests available for LF and their current applications as tools in mapping and transmission monitoring. The values of entomological indicators and parasite detection and speciation methods applied to vector populations are also discussed.
Contributors
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- By Edna Astbury-Ward, Toni Belfield, Joanna Brien, Sharon Cameron, Michael Carrette, Joyce Chai, Kelly Cleland, Rodica Comendant, Kelly R. Culwell, Caroline de Costa, James Drife, Joanna N. Erdman, Kristina Gemzell-Danielsson, Caitlin Gerdts, Daniel Grossman, Lisa Hallgarten, John Harris, Oskari Heikinheimo, Pak Chung Ho, Stelian Hodorogea, Roger Ingham, Helgi Johannsson, Anneli Kero, Helena Kopp Kallner, Pekka Lähteenmäki, Patricia A. Lohr, Richard Lyus, Wendy Macdowall, Sharon Moses, Emeka Oloto, Kate Paterson, Kerry Petersen, Sadie Regmi, Regina-Maria Renner, Pascale Roblin, Stephen C. Robson, Sam Rowlands, Irina Sagaidac, Joanna Speedie, Satu Suhonen, James Trussell, Kaye Wellings, Ellen Wiebe
- Edited by Sam Rowlands
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- Book:
- Abortion Care
- Published online:
- 05 September 2014
- Print publication:
- 28 August 2014, pp vii-x
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10 - Ghana
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- By Edith Wellington, John Gyapong, Sophia Twum-Barima, Moses Aikins, University of Ghana, John Britton, University of Nottingham
- Edited by Jeffrey Drope
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- Book:
- Tobacco Control in Africa
- Published by:
- Anthem Press
- Published online:
- 05 March 2012
- Print publication:
- 15 October 2011, pp 135-148
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Summary
Executive Summary
Despite considerable international activity in tobacco control, including shaping the Framework Convention on Tobacco Control (FCTC), comprehensive national legislation has been a struggle to achieve in Ghana. Accordingly, the most recent tobacco control efforts in Ghana, including the African Tobacco Situation Analysis (ATSA) initiative, have focused on advocating for national comprehensive legislation. Unfortunately, the legislation has been stalled for more than fi ve years. It is not clear how much support there is for the legislation in either the new cabinet or the national legislature. High-level changes in the health ministry have complicated these efforts, so the advocacy community has been once again regrouping to assess the potential for high-level support. In the interim, the tobacco control community has identifi ed other goals that may be more feasible in the short term. With comparatively low prevalence rates (approximately 5 percent) and a public generally compliant with informal tobacco control norms – particularly smoke-free public places of various sorts (e.g. hospitals, educational institutions, public transport, etc.) – a formalization of existing rules and regulations with an emphasis on enforcement could be sought concurrent to the pursuit of the broader legislation.
The Research and Development Division (RDD, formerly the Health Research Unit of the Ghana Health Service (GHS)) has been the principal leader of the ATSA team. While this unit is well-poised to conduct health research (it has strong ties to the Universities of Ghana and Nottingham) and public education, it has limitations, as an offi cial government entity, in advocating effectively for policy change.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
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- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Iodine nutritional status of children on the island of Tanna, Republic of Vanuatu
- Mu Li, Natalie McKelleher, Theto Moses, John Mark, Karen Byth, Gary Ma, Creswell J Eastman
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- Journal:
- Public Health Nutrition / Volume 12 / Issue 9 / September 2009
- Published online by Cambridge University Press:
- 01 September 2009, pp. 1512-1518
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Objective
To evaluate the iodine nutritional status of children living on the island of Tanna, Republic of Vanuatu.
DesignCross-sectional study. Urine and household salt samples were collected for iodine measurement. Thyroid volumes were measured by ultrasound. A food consumption frequency survey was carried out, particularly in relation to salt, iodine-rich foods and foods that containing thiocyanate, a potentially goitrogenic substance. Urinary thiocyanate levels were also measured.
SettingIsland rural communities in Tanna, Vanuatu.
SubjectsOne hundred and fifty-three schoolchildren between 8 and 10 years of age from four locations on the island participated.
ResultsThe median urinary iodine excretion (UIE) among the children was 49mg/l, indicating moderate iodine deficiency. This was corroborated by 27% of boys and 33% of girls having thyroid glands greater than the international standard for their age, and 36% of boys and 45% of girls having thyroid glands greater than the international standard for their body surface area based on ultrasonography. There was a highly statistically significant inverse correlation between thyroid volume and UIE for boys and girls (r = −0·444, P = 0·001 and r = −0·319, P = 0·005, respectively). There was no correlation between thiocyanate and UIE or thyroid volume. Only 34% of children reported to consume fish (tinned or fresh) on a weekly basis.
ConclusionsAgainst the common perception, the study has demonstrated that the children on the island of Tanna were in a state of moderate iodine deficiency. More data need to be collected from other Pacific Island countries in order to provide evidence for formulating public policy in prevention and control of iodine deficiency disorders in these nations.
Global frequency selection in the observed time-mean wakes of circular cylinders
- MOSES KHOR, JOHN SHERIDAN, MARK C. THOMPSON, KERRY HOURIGAN
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- Journal of Fluid Mechanics / Volume 601 / 25 April 2008
- Published online by Cambridge University Press:
- 25 April 2008, pp. 425-441
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Observations have been made of the time-mean velocity profile at midspan in the near-wake of circular cylinders at moderate Reynolds numbers between 600 and 4600, well beyond the Reynolds number of approximately 200 at which the wake becomes three-dimensional. The measured profiles are found to be represented quite accurately by a family of function profiles with known linear instability characteristics. The complex instability frequency is then determined as a function of wake position, using the function profiles. In general, the near wake undergoes a transition from convective to absolute instability; the distance downstream to the point of transition is found to increase over the Reynolds number range investigated. The emergence of a significant region of convective instability is consistent with the known appearance of Bloor–Gerrard vortices. The selected frequency of the wake instability is determined by the saddle-point criterion; the Strouhal numbers for Bénard–von Kármán vortex shedding are found to compare well with the values in the literature.
Managers’ perceptions of threats to the protected areas of Kenya: prioritization for effective management
- John Warui Kiringe, Moses Makonjio Okello, Sylvia W. Ekajul
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In Kenya knowledge of the relative severity of threats to protected areas and the vulnerability of these areas to any threats is lacking. Such information is required, however, for assessment of the effectiveness of management of the country’s protected areas, and to help identify critical management and policy weaknesses and priorities for improving management and allocating resources. We therefore studied the relative severity of threats to Kenya’s 50 protected areas and their relative vulnerability to such threats based on the perceptions of protected area managers. Ten threats were identified by these managers, of which the most severe were illegal bushmeat hunting, poaching of large mammals, human–wildlife conflicts, human encroachment, and loss of migration corridors and dispersal areas. Thirty-two (64%) protected areas were vulnerable to over half of the threats, 54% vulnerable to over six of the threats and 32% vulnerable to over seven of the threats. Protected areas in marine, forested/montane and inland wetland ecosystems were regarded as highly vulnerable to the perceived threats. Protected areas adjacent to urban/industrial and agricultural areas were vulnerable to most of the threats. Our findings demonstrate that protected areas in Kenya are increasingly threatened, that major threats needs to be mitigated, and that prioritization of protected areas for strategic actions is required for effective management.
Ecological and socioeconomic impacts of invasive alien species in island ecosystems
- JAMIE K. REASER, LAURA A. MEYERSON, QUENTIN CRONK, MAJ DE POORTER, L.G. ELDREGE, EDMUND GREEN, MOSES KAIRO, PEPETUA LATASI, RICHARD N. MACK, JOHN MAUREMOOTOO, DENNIS O'DOWD, WAREA ORAPA, SOETIKNO SASTROUTOMO, ALAN SAUNDERS, CLARE SHINE, SIGURDUR THRAINSSON, LELIUA VAIUTU
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- Environmental Conservation / Volume 34 / Issue 2 / June 2007
- Published online by Cambridge University Press:
- 25 May 2007, pp. 98-111
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Minimizing the impact of invasive alien species (IAS) on islands and elsewhere requires researchers to provide cogent information on the environmental and socioeconomic consequences of IAS to the public and policy makers. Unfortunately, this information has not been readily available owing to a paucity of scientific research and the failure of the scientific community to make their findings readily available to decision makers. This review explores the vulnerability of islands to biological invasion, reports on environmental and socioeconomic impacts of IAS on islands and provides guidance and information on technical resources that can help minimize the effects of IAS in island ecosystems. This assessment is intended to provide a holistic perspective on island-IAS dynamics, enable biologists and social scientists to identify information gaps that warrant further research and serve as a primer for policy makers seeking to minimize the impact of IAS on island systems. Case studies have been selected to reflect the most scientifically-reliable information on the impacts of IAS on islands. Sufficient evidence has emerged to conclude that IAS are the most significant drivers of population declines and species extinctions in island ecosystems worldwide. Clearly, IAS can also have significant socioeconomic impacts directly (for example human health) and indirectly through their effects on ecosystem goods and services. These impacts are manifest at all ecological levels and affect the poorest, as well as richest, island nations. The measures needed to prevent and minimize the impacts of IAS on island ecosystems are generally known. However, many island nations and territories lack the scientific and technical information, infrastructure and human and financial resources necessary to adequately address the problems caused by IAS. Because every nation is an exporter and importer of goods and services, every nation is also a facilitator and victim of the invasion of alien species. Wealthy nations therefore need to help raise the capacity of island nations and territories to minimize the spread and impact of IAS.
3 - Intangible heritage: museums and preservation
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- By David Grattan, Canadian Conservation Institute/Institut Canadien de Conservation, John Moses, Canadian Museum of Civilization/Musée Canadien des Civilisations
- Edited by G. E. Gorman, Sydney J. Shep
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- Preservation Management for Libraries, Archives and Museums
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- Facet
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- 08 June 2018
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- 18 August 2006, pp 42-53
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Summary
Introduction
Intangible heritage can have many forms, and the UNESCO Convention on its preservation has made only limited progress so far. The question of whether museums will play a larger role in its preservation is undecided. However, museums already deal with intangible heritage in two main ways. First, museums must consider the inherent intangible aspects of objects, including function or use, religious significance or practice, or artist's intent. Second, museums must consider the preservation of documentation such as written documents, film, photographs, and audio/videotape. This has become particularly important in recent years as the conservation challenges of these ephemeral materials have become more evident. Museums are also increasingly aware of their obligations to aboriginal communities and collections, and must adopt a professional aboriginal approach to the conservation, preservation, and guardianship of tangible and intangible cultural property.
What is intangible heritage?
Culture is not only demonstrated through tangible artefacts but is also manifested through intangible forms, such as language, music, theatre, attitudes, gestures, practices, customs and a whole range of other forms. Intangible heritage includes voices, values, traditions, languages, oral history, folk life, creativity, adaptability and indeed all that is distinctive of a people (International Council of Museums, 2004). This distinctiveness is popularly perceived through cuisine, clothing, forms of shelter, traditional skills and technologies, religious ceremonies, manners, customs, performing arts, storytelling and so forth. Many believe that globalization is a threat to intangible heritage (Galla, 2004), hence there is wide recognition that this form of heritage needs to be safeguarded. Accordingly, in 1993 UNESCO developed a Convention for this purpose. As of March 2006, 31 of the 191 member states of UNESCO have either approved or ratified the Convention.
However, concerns about intangible heritage are widespread and even though many nations are unable to sign, there are in fact many initiatives and much discussion about the topic. This theme was the topic of an International Council of Museums (ICOM) meeting in Seoul, in October 2004, and this was entirely appropriate as South Korea, a country with a very rich heritage, is one of the signatory nations.
Alternative brain organization after prenatal cerebral injury: Convergent fMRI and cognitive data
- JOAN STILES, PAMELA MOSES, KATHERINE ROE, NATACHA A. AKSHOOMOFF, DORIS TRAUNER, JOHN HESSELINK, ERIC C. WONG, LAWRENCE R. FRANK, RICHARD B. BUXTON
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- Journal:
- Journal of the International Neuropsychological Society / Volume 9 / Issue 4 / May 2003
- Published online by Cambridge University Press:
- 09 May 2003, pp. 604-622
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The current study presents both longitudinal behavioral data and functional activation data documenting the effects of early focal brain injury on the development of spatial analytic processing in two children, one with prenatal left hemisphere (LH) injury and one with right hemisphere (RH) injury. A substantial body of evidence has shown that adults and children with early, lateralized brain injury show evidence of spatial analytic deficits. LH injury compromises the ability to encode the parts of a spatial pattern, while RH injury impairs pattern integration. The two children described in this report show patterns of deficit consistent with the site of their injury. In the current study, their longitudinal behavioral data spanning the age range from preschool to adolescence are presented in conjunction with data from a functional magnetic resonance imaging (fMRI) study of spatial processing. The activation results provide evidence that alternative profiles of neural organization can arise following early focal brain injury, and document where in the brain spatial functions are carried out when regions that normally mediate them are damaged. In addition, the coupling of the activation with the behavioral data allows us to go beyond the simple mapping of functional sites, to ask questions about how those sites may have come to mediate the spatial functions. (JINS, 2003, 9, 604–622.)